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Supports: TIFF, TIF
TIFF (Tagged Image File Format) is the workhorse of high-fidelity imaging — uncompressed or losslessly compressed pixels, 16-bit-per-channel depth, multi-page containers, and broad scientific / publishing acceptance. The trouble is that a folder of 600 TIFFs is unplayable on a phone, unshareable in a Slack channel, and unembeddable in a YouTube upload. MP4 with H.264 is the universal delivery format — supported in every modern browser, on iOS / Android / Smart TVs, and accepted by every social platform.
| Property | TIFF | MP4 (H.264) |
|---|---|---|
| Type | Still image container (optionally multi-page) | Video container with audio + subtitles |
| Compression | None, LZW, ZIP, JPEG, ZSTD, or PackBits | Lossy H.264 / H.265 / AV1 inter-frame compression |
| Color depth | 1-, 8-, 16-, 32-bit per channel; CMYK / RGB / Lab / grayscale | 8-bit per channel (10-bit with H.265 Main10) |
| Maximum file size | 4 GB standard TIFF; 18 exabytes with BigTIFF | No practical cap (containers commonly 4 GB+ supported) |
| Audio support | No | Yes (AAC, MP3, AC3, Opus, FLAC, more) |
| Animation / sequence | Multi-page TIFF carries pages but no playback timing | Full timeline with frame rate, duration, seeking |
| Browser playback | Not supported in Chrome / Firefox / Edge / Safari | Universal — every modern browser since 2014 |
| Typical use | Archival, scientific, print, scans | Streaming, social, mobile, web embed |
| Editing software | Photoshop, GIMP, Photopea, ImageJ, ImageMagick | Premiere, DaVinci Resolve, Final Cut, CapCut, ffmpeg |
| Source type | Frames per second | When to use |
|---|---|---|
| Cinematic slideshow | 24 fps (1/24 sec/frame) | Polished sequence with motion-blur feel |
| Smooth time-lapse | 30 fps (1/30 sec/frame) | Standard social / web playback |
| Fast time-lapse / scientific | 60 fps (1/60 sec/frame) | Cloud movement, traffic, fast cell division |
| Slow time-lapse | 15 fps | Plant growth, slow geology, contemplative pacing |
| Plain slideshow | 0.2-0.33 fps (3-5 sec/frame) | Photo gallery, family scans, presentation reel |
| Microscopy review | 10 fps (1/10 sec/frame) | Lab-bench review of cellular processes |
Yes — the default "Merge images" mode stacks every uploaded TIFF into a single MP4 timeline in alphabetical / numerical filename order. Name your files with zero-padded numbers (frame_0001.tif, frame_0002.tif, etc.) for reliable ordering. To render each TIFF as its own short clip instead, switch the merge strategy to "Video per image."
H.264 in standard MP4 is 8-bit per channel (24-bit RGB), so the 16-bit-per-channel depth from microscopes, scientific cameras, and HDR scans is mapped down at encode time. Colors are preserved faithfully visually, but the extra dynamic range is gone. If you need to keep 10-bit precision for HDR / grading, render to H.265 Main10 (use TIFF to HEVC) or keep the TIFFs as the master and only deliver MP4 for sharing.
TIFF stores every frame independently and uncompressed (or losslessly compressed). H.264 stores keyframes occasionally and predicts everything else from inter-frame motion vectors — for a time-lapse where consecutive frames overlap heavily, the resulting MP4 is typically 50-200× smaller than the source TIFF folder. A 4 GB folder of TIFFs commonly fits in a 20-80 MB MP4 with no visible quality loss.
24 or 30 fps for cinema-style smoothness; 60 fps if the source captured fast motion (clouds, traffic, fast cell division); 15 fps for slow / contemplative subjects (plant growth, slow geology). For a plain photo slideshow, 3-5 seconds per frame (0.2-0.33 fps) is comfortable for viewers. The Image Duration control lets you set this in human units (seconds per frame) instead of fps.
Yes. H.264 in an MP4 container is the universal video format — it plays natively in every modern browser (Chrome, Firefox, Safari, Edge), on every iPhone and Android, on Apple TV / Roku / Chromecast / Fire TV / smart TVs, and uploads cleanly to YouTube, Instagram, TikTok, LinkedIn, Slack, Discord, and Google Drive without re-encoding. caniuse.com tracks H.264 / MP4 support at effectively 100% of in-use browsers.
The TIFF-to-MP4 page renders silent video by default (TIFFs carry no audio). If you need audio, render the silent MP4 first, then drop it into a separate video editor (CapCut, DaVinci Resolve, iMovie, Premiere) to layer in music or voiceover, or use ffmpeg's -i video.mp4 -i audio.mp3 -c:v copy -c:a aac out.mp4 to mux a pre-prepared audio track without re-encoding the video.
Both work. A multi-page TIFF is treated as an in-order frame sequence — every page becomes a frame in the output MP4 with the Image Duration you picked. This is convenient for scanned PDFs converted to multi-page TIFF, microscope z-stacks, and fax-archive TIFFs.
Constant Quality (CRF in ffmpeg terms) holds visual quality steady and lets bitrate vary — best when you don't care about exact file size but want the cleanest result for a given quality target. Constraint Quality caps the bitrate (or the peak bitrate) so the file size lands inside a predictable budget — best when you have a hard upload limit (e.g., a 100 MB attachment cap, a streaming platform's recommended bitrate). For archival sequences pick Constant Quality + Very High; for tight email or chat uploads pick Constraint Quality + Medium.
GIF is limited to a 256-color palette and has no audio — fine for short looping graphics but lossy in color and large in file size for anything longer than a few seconds. MP4 with H.264 keeps full 24-bit color, plays anywhere a GIF plays, and is typically 5-10× smaller for the same duration and quality. See TIFF to GIF if you specifically need a looping clip for chat reactions or embeds where MP4 isn't accepted.